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University of Pennsylvania

University of Pennsylvania

Penn Diabetes Research Center
Smilow Center for Translational Research
3400 Civic Center Boulevard, 12th floor
Philadelphia, PA 19104
United States

Google Map
DRC Website
Center Director: Mitchell A Lazar MD PhD


The DRC participates in the nationwide inter-disciplinary program established over 40 years ago by the NIDDK to foster diabetes research. The Penn DRC is centered in the Smilow Center for Translational Research at the University of Pennsylvania Perelman School of Medicine, and serves over 120 diabetes-oriented investigators including many from other schools within the University of Pennsylvania as well as additional institutions from the mid-Atlantic region.

The Penn DRC is highly interactive and interdisciplinary, representing many basic science and clinical departments at Penn and the other institutions, and supports research in diabetes and obesity via Scientific Cores, a Pilot and Feasibility Grant Program, and a series of seminars, retreats, and other academic enrichment activities that facilitate communication, collaboration of DRC investigators in the pursuit of new understanding, treatment, and cures for diabetes, obesity, and related metabolic disorders.

The IDOM and DRC create a unique and exciting environment within a great university and prominent health system.

Partner Institutions

Research Cores

Assay - Human & Laboratory Animal
Penn Radioimmunoassay and Biomarkers CoreMichael R Rickels MD MS
The Radioimmunoassay and Biomarkers Core offers a large number of high quality immunoassay services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research.
Islet Biology & Metabolism
Penn Islet Cell Biology CoreDoris A Stoffers MD PhD
The Islet Cell Biology Core provides DRC members with state of the art support including experimental design, islet isolation, and performance of and/or training in an expansive range of assays for physiological and morphometric assessment of pancreatic islet function and growth.
Molecular Biology, Genetics & Genomics
Penn Functional Genomics CoreKlaus H Kaestner PhD
The FGC provides state-of-the-art experiment planning, sample preparation, quality assessment, library construction, DNA sequencing, and data analysis services to DRC members.
Protein, Proteomics, Metabolomics & Mass Spectrometry
Regional Metabolomics and Fluxomics Core at PrincetonJoshua D Rabinowitz MD PhD
The primary objective of the Regional Metabolomics and Fluxomics Core is to provide DRC members with state-of-the-art metabolomics and flux analysis services, including pioneering capabilities like spatial fluxomics.
Specialized Animal & Gene Modification
Penn Transgenic Mouse Genome Editing CoreDouglas J Epstein PhD
The Transgenic Transgenic Mouse Genome Editing Core has generated a wide range of transgenic and gene-targeted mouse lines that have proven to be powerful tools for the study of the molecular biology and physiology of Type I and Type II diabetes.