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Predictors of Time-in-Range (70-180 mg/dL) Achieved Using a Closed-Loop Control System.

Citation
Schoelwer, M. J., et al. “Predictors Of Time-In-Range (70-180 Mg/Dl) Achieved Using A Closed-Loop Control System.”. Diabetes Technology & Therapeutics.
Center Stanford University
Author Melissa J Schoelwer, Lauren G Kanapka, Paul Wadwa, Marc D Breton, Katrina J Ruedy, Laya Ekhlaspour, Gregory P Forlenza, Erin C Cobry, Laurel H Messer, Eda Cengiz, Emily Jost, Lori Carria, Emma Emory, Liana J Hsu, Stuart A Weinzimer, Bruce A Buckingham, Rayhan A Lal, Mary Clancy Oliveri, Craig C Kollman, Betsy B Dokken, Daniel R Cherñavvsky, Roy W Beck, Mark D Deboer, iDCL Trial Research Group
Keywords Closed-loop systems, Insulin pump, Time-in-range, type 1 diabetes
Abstract

Studies of closed-loop control (CLC) in patients with type 1 diabetes (T1D) consistently demonstrate improvements in glycemic control as measured by increased time-in-range (TIR) 70-180 mg/dL. However, clinical predictors of TIR in users of CLC systems are needed. We analyzed data from 100 children aged 6-13 years with T1D using the Tandem Control-IQ CLC system during a randomized trial or subsequent extension phase. Continuous glucose monitor data were collected at baseline and during 12-16 weeks of CLC use. Participants were stratified into quartiles of TIR on CLC to compare clinical characteristics. TIR for those in the first, second, third, and fourth quartiles was 54%, 65%, 71%, and 78%, respectively. Lower baseline TIR was associated with lower TIR on CLC ( = 0.69,  < 0.001). However, lower baseline TIR was also associated with greater improvement in TIR on CLC ( = -0.81,  < 0.001). During CLC, participants in the highest versus lowest TIR-quartile administered more user-initiated boluses daily (8.5 ± 2.8 vs. 5.8 ± 2.6,  < 0.001) and received fewer automated boluses (3.5 ± 1.0 vs. 6.0 ± 1.6,  < 0.001). Participants in the lowest (vs. the highest) TIR-quartile received more insulin per body weight (1.13 ± 0.27 vs. 0.87 ± 0.20 U/kg/d,  = 0.008). However, in a multivariate model adjusting for baseline TIR, user-initiated boluses and insulin-per-body-weight were no longer significant. Higher baseline TIR is the strongest predictor of TIR on CLC in children with T1D. However, lower baseline TIR is associated with the greatest improvement in TIR. As with open-loop systems, user engagement is important for optimal glycemic control.

Year of Publication
2021
Journal
Diabetes technology & therapeutics
Date Published
03/2021
ISSN Number
1557-8593
DOI
10.1089/dia.2020.0646
Alternate Journal
Diabetes Technol Ther
PMID
33689454
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