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Ambulatory glucose profile analysis of the juvenile diabetes research foundation continuous glucose monitoring dataset-Applications to the pediatric diabetes population.

Citation
Forlenza, G. P., et al. “Ambulatory Glucose Profile Analysis Of The Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Dataset-Applications To The Pediatric Diabetes Population.”. Pediatric Diabetes, pp. 622-628.
Center Stanford University
Author Gregory P Forlenza, Laura L Pyle, David M Maahs, Timothy C Dunn
Keywords ambulatory glucose profile, Continuous glucose monitor, diabetes
Abstract

BACKGROUND: Increased continuous glucose monitor (CGM) use presents both the benefit and burden of increased data for clinicians to rapidly analyze. The ambulatory glucose profile (AGP) is an evolving a universal software report for CGM data analysis.

OBJECTIVES/HYPOTHESES: We utilized the Juvenile Diabetes Research Foundation-CGM dataset to evaluate the AGP across a broad spectrum of patients to show how AGP can be used clinically to assist with CGM-related decision making. We hypothesized that AGP metrics would be different across age and HbA1c strata.

SUBJECTS: AGPs were generated from the JDRF-CGM trial dataset for all periods during which there were ≥10 days of CGM coverage in the 2 weeks adjacent to an HbA1c measurement yielding 1101 AGPs for 393 unique subjects.

METHODS: AGPs were stratified by age group (8-14, 15-24, and ≥25 years) and HbA1c (within or above target for age) and compared for between group differences in AGP metrics via two-factor ANOVA. Glycemic differences between time periods were analyzed via segmented regression analysis.

RESULTS: Glucose exposure (average and estimated A1c) and variability (standard deviation and interquartile range) were different between the low and high HbA1c levels. Within a given HbA1c level all age groups were significantly different from each other with older patients having lower averages with less variability than younger patients.

CONCLUSIONS: AGP analysis of the JDRF-CGM data highlights significant differences in glycemic profiles between pediatric and adult age groups and between well and less well-controlled patient populations.

Year of Publication
2017
Journal
Pediatric diabetes
Volume
18
Issue
7
Number of Pages
622-628
Date Published
11/2017
ISSN Number
1399-5448
DOI
10.1111/pedi.12474
Alternate Journal
Pediatr Diabetes
PMID
27878929
PMCID
PMC7162536
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