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Regeneration of fat cells from myofibroblasts during wound healing.

Citation
Plikus, M., et al. “Regeneration Of Fat Cells From Myofibroblasts During Wound Healing.”. Science (New York, N.y.), pp. 748-752.
Center University of Pennsylvania
Author Maksim Plikus V, Christian F Guerrero-Juarez, Mayumi Ito, Yun Rose Li, Priya H Dedhia, Ying Zheng, Mengle Shao, Denise L Gay, Raul Ramos, Tsai-Ching Hsi, Ji Won Oh, Xiaojie Wang, Amanda Ramirez, Sara E Konopelski, Arijh Elzein, Anne Wang, Rarinthip June Supapannachart, Hye-Lim Lee, Chae Ho Lim, Arben Nace, Amy Guo, Elsa Treffeisen, Thomas Andl, Ricardo N Ramirez, Rabi Murad, Stefan Offermanns, Daniel Metzger, Pierre Chambon, Alan D Widgerow, Tai-Lan Tuan, Ali Mortazavi, Rana K Gupta, Bruce A Hamilton, Sarah E Millar, Patrick Seale, Warren S Pear, Mitchell A Lazar, George Cotsarelis
Abstract

Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.

Year of Publication
2017
Journal
Science (New York, N.Y.)
Volume
355
Issue
6326
Number of Pages
748-752
Date Published
12/2017
ISSN Number
1095-9203
DOI
10.1126/science.aai8792
Alternate Journal
Science
PMID
28059714
PMCID
PMC5464786
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