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Biochemical and cellular properties of insulin receptor signalling.

Citation
Haeusler, R. A., et al. “Biochemical And Cellular Properties Of Insulin Receptor Signalling.”. Nature Reviews. Molecular Cell Biology, pp. 31-44.
Center Albert Einstein College of Medicine Columbia University
Multicenter
Multicenter
Author Rebecca A Haeusler, Timothy E McGraw, Domenico Accili
Abstract

The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β-cells, genetic and acquired abnormalities of insulin action underlie the far more common conditions of type 2 diabetes, obesity and insulin resistance. The latter predisposes to diseases ranging from hypertension to Alzheimer disease and cancer. Hence, understanding the biochemical and cellular properties of insulin receptor signalling is arguably a priority in biomedical research. In the past decade, major progress has led to the delineation of mechanisms of glucose transport, lipid synthesis, storage and mobilization. In addition to direct effects of insulin on signalling kinases and metabolic enzymes, the discovery of mechanisms of insulin-regulated gene transcription has led to a reassessment of the general principles of insulin action. These advances will accelerate the discovery of new treatment modalities for diabetes.

Year of Publication
2018
Journal
Nature reviews. Molecular cell biology
Volume
19
Issue
1
Number of Pages
31-44
Date Published
01/2018
ISSN Number
1471-0080
DOI
10.1038/nrm.2017.89
Alternate Journal
Nat. Rev. Mol. Cell Biol.
PMID
28974775
PMCID
PMC5894887
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