Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer.
| Citation | Moreira, Leticia, et al. “Pancreas 3D Organoids: Current and Future Aspects As a Research Platform for Personalized Medicine in Pancreatic Cancer”. 2018. Cellular and Molecular Gastroenterology and Hepatology, vol. 5, no. 3, 2018, pp. 289–298. |
| Center | University of Pennsylvania |
| Author | Leticia Moreira, Basil Bakir, Priya Chatterji, Zahra Dantes, Maximilian Reichert, Anil K Rustgi |
| Keywords | 3D Organoids, 3D, 3-dimensional, Adenocarcinoma, GEMMs, genetically engineered mouse models, PDAC, pancreatic ductal adenocarcinoma, PDX, patient-derived tumor xenografts, PanIN, pancreatic intraepithelial neoplasia, pancreas, Personalized medicine |
| Abstract |
Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine. |
| Year of Publication |
2018
|
| Journal |
Cellular and molecular gastroenterology and hepatology
|
| Volume |
5
|
| Issue |
3
|
| Number of Pages |
289-298
|
| Date Published |
03/2018
|
| ISSN Number |
2352-345X
|
| DOI |
10.1016/j.jcmgh.2017.12.004
|
| Alternate Journal |
Cell Mol Gastroenterol Hepatol
|
| PMID |
29541683
|
| PMCID |
PMC5849862
|
| Download citation |