| Center |
 Vanderbilt University
|
| Award Year | 2012 |
| Pilot Study | Two pore-domain potassium channels: Pancreatic islet expression and function |
| Awardee | David A Jacobson PhD |
| Abstract |
This project plans to test the hypothesis that K2P channels modulate the membrane potential of mouse and human islet cells regulating calcium influx and hormone secretion. The specific objectives are to: A. Define the K2P channels of mouse and human islet cells, B. Identify the biophysical regulation of islet K2P channels and their influence on membrane potential and hormone secretion, and C. Characterize the pharmacology of islet K2P channels and utilize this pharmacology to address the influence of K2P channels on human and mouse islet cell electrical activity and hormone secretion. |