Center | Vanderbilt University |
Award Year | 2016 |
Pilot Study | Mitigation of hypothalamic inflammation via ablation of microglial IKKbeta |
Awardee | Nathan C Bingham MD PhD |
Abstract |
Rodents fed a high-fat diet (HFD), upregulate proinflammatory cytokines within the mediobasal hypothalamus (MBH), an important center of neuronal control of appetite and metabolism. This metabolically-induced inflammation, or ‘metaflammation,’ contributes to central leptin resistance, increased caloric intake, and obesity. These results run contrary to a large body of work that has identified hypothalamic inflammatory signaling as a mediator of the sickness-induced cachexia response triggered in response to classic inflammatory stimuli such as injury, infection, cancer, or autoimmunity. |
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