Mechanisms and consequences of HDL microRNA communication in diabetes

We have previously reported that HDL transports and delivers beta-cell specific miRNAs to recipient hepatocytes. Therefore, we aim to determine if beta cells export specific miRNAs to HDL to be delivered to theliver as part of a novel endocrine-like communication network. Furthermore, we aim to determine if this cell-tocellcommunication is altered in hyperglycemia and corrected by Colesevelam treatment, a diabetes drug thathas been found to improve beat cell function and insulin secretion. Results from this pilot and feasibility studywill provide a foundation of basic understanding into a new paradigm of cell communication that likely contributes to systemic glucose homeostasis.Extracellular RNA and HDL-mediated intercellular communication has tremendous applicability to manydiseases. As new investigator to Vanderbilt, I have a strong interest in expanding my research program toinclude diabetes, and have a significant interest in a research career in diabetes. Nevertheless, myinvestigation into diabetes is just beginning; therefore, this award will provide the necessary funds to obtainsufficient data for individual grant support in the field of diabetes.