Vanderbilt Animal Metabolic Physiology Core

Overview

The Animal Metabolic Physiological Core (AMPC) is a new Vanderbilt Diabetes Research Center (VDRC) Core. In prior VDRC cycles, mouse services for VDRC investigators had been provided by the Vanderbilt Mouse Metabolic Phenotyping Center (MMPC).

The AMPC will provide state-of-the-art research techniques and expert guidance in integrative metabolic physiology to VDRC investigators.

Services

Serving Vanderbilt Investigators

Metabolic Regulation

Regulation of metabolic fluxes in vivo including clamp and exercise protocols. Arterial and venous catheterization a week before experiments allow studies without stress. Intravital imaging and novel surgical preparations are available.

Body Weight Regulation

Regulation of body weight from whole body mitochondria. Metabolic and behavioral components of energy balance are measured with high precision and time resolution. Mouse bariatric and other surgical models are used to study weight loss.

Analytical Resources

Specialized analytical techniques consist of four subcores: (1) Hormone Assay and Analytical Services, (2) Lipids, Lipoproteins, and Atherosclerosis, (3) Mouse Pathology, (4) Metabolic Flux Analysis.

Surgical Services

Specialized surgical procedures for indwelling catheters, CNS implantations, study of GI-liver function, and parabiosis. Development of new surgical procedures and surgical training are also available.