The Dempsey lab studies the development and function of epithelial cells in gastrointestinal tract during normal physiology and disease. In particular, we are interested in how extracellular signals regulate intestinal homeostasis and the role of cellular plasticity during intestinal regeneration and in colitis-associated cancer. We use genetically engineered mouse models and both adult and iPS-derived intestinal stem cell enteroid cultures to study these events.
Dr. Peter Dempsey's research interests include intestinal stem cell programming and differentiation, cellular plasticity, and organoid models to study intestinal disease.
