The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
| Citation | . “The Extracellular Rna Communication Consortium: Establishing Foundational Knowledge And Technologies For Extracellular Rna Research.”. Cell, pp. 231-242. |
| Center | University of Michigan |
| Author | Saumya Das, Extracellular RNA Communication Consortium, Mark Ansel, Markus Bitzer, Xandra O Breakefield, Alain Charest, David J Galas, Mark B Gerstein, Mihir Gupta, Aleksandar Milosavljevic, Michael T McManus, Tushar Patel, Robert L Raffai, Joel Rozowsky, Matthew E Roth, Julie A Saugstad, Kendall Van Keuren-Jensen, Alissa M Weaver, Louise C Laurent |
| Abstract |
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. |
| Year of Publication |
2019
|
| Journal |
Cell
|
| Volume |
177
|
| Issue |
2
|
| Number of Pages |
231-242
|
| Date Published |
12/2019
|
| ISSN Number |
1097-4172
|
| DOI |
10.1016/j.cell.2019.03.023
|
| Alternate Journal |
Cell
|
| PMID |
30951667
|
| PMCID |
PMC6601620
|
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