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Noninvasive glucose detection in exhaled breath condensate.

Citation
Tankasala, D., and J. C. Linnes. “Noninvasive Glucose Detection In Exhaled Breath Condensate.”. Translational Research : The Journal Of Laboratory And Clinical Medicine, pp. 1-22.
Center Indiana University
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Author Divya Tankasala, Jacqueline C Linnes
Abstract

Two-thirds of patients with diabetes avoid regularly monitoring their blood glucose levels because of the painful and invasive nature of current blood glucose detection. As an alternative to blood sample collection, exhaled breath condensate (EBC) has emerged as a promising noninvasive sample from which to monitor glucose levels. However, this dilute sample matrix requires sensors capable of detecting glucose with high resolution at nanomolar and micromolar concentrations. Recent developments in EBC collection methods and highly sensitive glucose biosensors provide a path toward enabling robust and sensitive glucose detection in EBC. This review addresses current and emerging EBC collection and glucose sensing modalities capable of quantifying glucose in EBC samples. We highlight the opportunities and challenges for development and integration of EBC glucose detection systems that will enable clinically robust and accurate EBC glucose measurements for improved glycemic control.

Year of Publication
2019
Journal
Translational research : the journal of laboratory and clinical medicine
Volume
213
Number of Pages
1-22
Date Published
11/2019
ISSN Number
1878-1810
DOI
10.1016/j.trsl.2019.05.006
Alternate Journal
Transl Res
PMID
31194942
PMCID
PMC6783357
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