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Change in CT-measured abdominal subcutaneous and visceral but not thigh fat areas predict future insulin sensitivity.

Citation
Liu, Amy W, et al. “Change in CT-Measured Abdominal Subcutaneous and Visceral But Not Thigh Fat Areas Predict Future Insulin Sensitivity”. 2019. Diabetes Research and Clinical Practice, vol. 154, 2019, pp. 17–26.
Center University of Washington
Author Amy W Liu, Sun Ok Song, Tomoshige Hayashi, Kyoko K Sato, Steven E Kahn, Donna L Leonetti, Wilfred Y Fujimoto, Edward J Boyko
Keywords HOMA-IR, insulin sensitivity, Matsuda index, Visceral fat
Abstract

AIMS: We examined the longitudinal association between change in body composition directly measured by computed tomography (CT) and future insulin sensitivity.

METHODS: This was a prospective study with 10 years of follow-up with 297 Japanese-American without diabetes. Intra-abdominal fat area (IAFA) and abdominal subcutaneous fat area (SCFA), and thigh SCFA were measured by CT. Insulin sensitivity was calculated by HOMA-IR and the Matsuda index.

RESULTS: Baseline and change in IAFA were significantly and independently associated with change in HOMA-IR and Matsuda index during follow-up. In multivariate analysis, IAFA and 10-year change in IAFA (Δ IAFA) was significantly and positively associated with 10-year HOMA-IR (p < 0.001) and significantly and negatively associated with 10-year Matsuda index (p < 0.001). The association with Matsuda index though was non-linear and best modeled as a quadratic function (Δ IAFA + Δ IAFA). No significant associations in multivariate analyses were seen between thigh SCFA and insulin sensitivity or abdominal SCFA and HOMA-IR but an increase in abdominal SCFA was associated with diminished insulin sensitivity measured by the Matsuda index.

CONCLUSIONS: An increase in visceral adiposity predicts diminished insulin sensitivity over 10 years of follow-up independent of the size of this adipose depot at baseline.

Year of Publication
2019
Journal
Diabetes research and clinical practice
Volume
154
Number of Pages
17-26
Date Published
08/2019
ISSN Number
1872-8227
DOI
10.1016/j.diabres.2019.06.008
Alternate Journal
Diabetes Res. Clin. Pract.
PMID
31228493
PMCID
PMC6698223
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