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- Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.
Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.
Citation | “Serum Mir-204 Is An Early Biomarker Of Type 1 Diabetes-Associated Pancreatic Beta-Cell Loss.”. American Journal Of Physiology. Endocrinology And Metabolism, pp. E723-E730. . |
Center | University of Alabama at Birmingham |
Author | Guanlan Xu, Lance A Thielen, Junqin Chen, Truman B Grayson, Tiffany Grimes, Louis Bridges, Hubert M Tse, Blair Smith, Rakesh Patel, Peng Li, Carmella Evans-Molina, Fernando Ovalle, Anath Shalev |
Keywords | T1D, beta cell death, biomarker, miR-204 |
Abstract |
Pancreatic beta-cell death is a major factor in the pathogenesis of type 1 diabetes (T1D), but straightforward methods to measure beta-cell loss in humans are lacking, underlining the need for novel biomarkers. Using studies in INS-1 cells, human islets, diabetic mice, and serum samples of subjects with T1D at different stages, we have identified serum miR-204 as an early biomarker of T1D-associated beta-cell loss in humans. MiR-204 is a highly enriched microRNA in human beta-cells, and we found that it is released from dying beta-cells and detectable in human serum. We further discovered that serum miR-204 was elevated in children and adults with T1D and in autoantibody-positive at-risk subjects but not in type 2 diabetes or other autoimmune diseases and was inversely correlated with remaining beta-cell function in recent-onset T1D. Thus, serum miR-204 may provide a much needed novel approach to assess early T1D-associated human beta-cell loss even before onset of overt disease. |
Year of Publication |
2019
|
Journal |
American journal of physiology. Endocrinology and metabolism
|
Volume |
317
|
Issue |
4
|
Number of Pages |
E723-E730
|
Date Published |
12/2019
|
ISSN Number |
1522-1555
|
DOI |
10.1152/ajpendo.00122.2019
|
Alternate Journal |
Am. J. Physiol. Endocrinol. Metab.
|
PMID |
31408375
|
PMCID |
PMC6842918
|
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