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Time-restricted feeding mitigates obesity through adipocyte thermogenesis.

Citation
Hepler, C., et al. “Time-Restricted Feeding Mitigates Obesity Through Adipocyte Thermogenesis.”. Science (New York, N.y.), pp. 276-284.
Center University of Chicago
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Author Chelsea Hepler, Benjamin J Weidemann, Nathan J Waldeck, Biliana Marcheva, Jonathan Cedernaes, Anneke K Thorne, Yumiko Kobayashi, Rino Nozawa, Marsha Newman V, Peng Gao, Mengle Shao, Kathryn M Ramsey, Rana K Gupta, Joseph Bass
Abstract

Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting feeding to the active period mitigates metabolic syndrome through mechanisms that remain unknown. We found that genetic enhancement of adipocyte thermogenesis through ablation of the zinc finger protein 423 (ZFP423) attenuated obesity caused by consumption of a high-fat diet during the inactive (light) period by increasing futile creatine cycling in mice. Circadian control of adipocyte creatine metabolism underlies the timing of diet-induced thermogenesis, and enhancement of adipocyte circadian rhythms through overexpression of the clock activator brain and muscle Arnt-like protein-1 (BMAL1) ameliorated metabolic complications during diet-induced obesity. These findings uncover rhythmic creatine-mediated thermogenesis as an essential mechanism that drives metabolic benefits during time-restricted feeding.

Year of Publication
2022
Journal
Science (New York, N.Y.)
Volume
378
Issue
6617
Number of Pages
276-284
Date Published
10/2022
ISSN Number
1095-9203
DOI
10.1126/science.abl8007
Alternate Journal
Science
PMID
36264811
PMCID
PMC10150371
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