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Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.

Citation
Padmanabhan, V., et al. “Praegnatio Perturbatio-Impact Of Endocrine-Disrupting Chemicals.”. Endocrine Reviews, pp. 295-353.
Center University of Michigan
Author Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa
Keywords birth outcomes, endocrine-disrupting chemicals, placenta, pregnancy
Abstract

The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes receiving considerable attention in recent years is gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed to a multitude of environmental chemicals with known endocrine-disrupting properties, and evidence suggests exposure to these EDCs have the potential to disrupt the maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes-a risk factor for adult-onset noncommunicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediators involved, and the research directions on which to focus future investigations to help alleviate the adverse effects of EDC exposure.

Year of Publication
2021
Journal
Endocrine reviews
Volume
42
Issue
3
Number of Pages
295-353
Date Published
05/2021
ISSN Number
1945-7189
DOI
10.1210/endrev/bnaa035
Alternate Journal
Endocr Rev
PMID
33388776
PMCID
PMC8152448
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