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Peroxisomes as Cellular Adaptors to Metabolic and Environmental Stress.

Citation
He, A., et al. “Peroxisomes As Cellular Adaptors To Metabolic And Environmental Stress.”. Trends In Cell Biology.
Center Washington University in St Louis
Author Anyuan He, John M Dean, Irfan J Lodhi
Keywords ether lipid, lipid metabolism, peroxisome, plasmalogen, reactive oxygen species, Stress
Abstract

Peroxisomes are involved in multiple metabolic processes, including fatty acid oxidation, ether lipid synthesis, and reactive oxygen species (ROS) metabolism. Recent studies suggest that peroxisomes are critical mediators of cellular responses to various forms of stress, including oxidative stress, hypoxia, starvation, cold exposure, and noise. As dynamic organelles, peroxisomes can modulate their proliferation, morphology, and movement within cells, and engage in crosstalk with other organelles in response to external cues. Although peroxisome-derived hydrogen peroxide has a key role in cellular signaling related to stress, emerging studies suggest that other products of peroxisomal metabolism, such as acetyl-CoA and ether lipids, are also important for metabolic adaptation to stress. Here, we review molecular mechanisms through which peroxisomes regulate metabolic and environmental stress.

Year of Publication
2021
Journal
Trends in cell biology
Date Published
03/2021
ISSN Number
1879-3088
DOI
10.1016/j.tcb.2021.02.005
Alternate Journal
Trends Cell Biol
PMID
33674166
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