- Home
- Featured Publications
- Center Publications
- Creatine kinase B controls futile creatine cycling in thermogenic fat.
Creatine kinase B controls futile creatine cycling in thermogenic fat.
Citation | “Creatine Kinase B Controls Futile Creatine Cycling In Thermogenic Fat.”. Nature, pp. 480-485. . |
Center | Boston Area |
Author | Janane F Rahbani, Anna Roesler, Mohammed F Hussain, Bozena Samborska, Christien B Dykstra, Linus Tsai, Mark P Jedrychowski, Laurent Vergnes, Karen Reue, Bruce M Spiegelman, Lawrence Kazak |
Abstract |
Obesity increases the risk of mortality because of metabolic sequelae such as type 2 diabetes and cardiovascular disease. Thermogenesis by adipocytes can counteract obesity and metabolic diseases. In thermogenic fat, creatine liberates a molar excess of mitochondrial ADP-purportedly via a phosphorylation cycle-to drive thermogenic respiration. However, the proteins that control this futile creatine cycle are unknown. Here we show that creatine kinase B (CKB) is indispensable for thermogenesis resulting from the futile creatine cycle, during which it traffics to mitochondria using an internal mitochondrial targeting sequence. CKB is powerfully induced by thermogenic stimuli in both mouse and human adipocytes. Adipocyte-selective inactivation of Ckb in mice diminishes thermogenic capacity, increases predisposition to obesity, and disrupts glucose homeostasis. CKB is therefore a key effector of the futile creatine cycle. |
Year of Publication |
2021
|
Journal |
Nature
|
Volume |
590
|
Issue |
7846
|
Number of Pages |
480-485
|
Date Published |
12/2021
|
ISSN Number |
1476-4687
|
DOI |
10.1038/s41586-021-03221-y
|
Alternate Journal |
Nature
|
PMID |
33597756
|
Download citation |