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Mitochondrial Lipid Signaling and Adaptive Thermogenesis.

Citation
Von Bank, H., et al. “Mitochondrial Lipid Signaling And Adaptive Thermogenesis.”. Metabolites.
Center Washington University in St Louis
Author Helaina Von Bank, Mae Hurtado-Thiele, Nanami Oshimura, Judith Simcox
Keywords acylcarnitine, brown adipose tissue, cardiolipin, free fatty acid, glycerolipids, ketone, lipids, mitochondria, plasmalogen, thermogenesis
Abstract

Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling protein 1 (UCP1), which allows for the diffusion of protons through the mitochondrial inner membrane to produce heat. To support this energy demanding process, the mitochondria in brown and beige adipocytes increase oxidation of glucose, amino acids, and lipids. This review article explores the various mitochondria-produced and processed lipids that regulate thermogenesis including cardiolipins, free fatty acids, and acylcarnitines. These lipids play a number of roles in thermogenic adipose tissue including structural support of UCP1, transcriptional regulation, fuel source, and activation of cell signaling cascades.

Year of Publication
2021
Journal
Metabolites
Volume
11
Issue
2
Date Published
02/2021
ISSN Number
2218-1989
DOI
10.3390/metabo11020124
Alternate Journal
Metabolites
PMID
33671745
PMCID
PMC7926967
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