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- High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains.
High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains.
Citation | “High-Fat Feeding Disrupts Daily Eating Behavior Rhythms In Obesity-Prone But Not In Obesity-Resistant Male Inbred Mouse Strains.”. American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology. . |
Center | Washington University in St Louis |
Author | Tiffany N Buckley, Oluwabukola Omotola, Luke A Archer, Cameron R Rostron, Ellora P Kamineni, Josie D Llanora, Jeffrey M Chalfant, Feitong Lei, Emily Slade, Julie S Pendergast |
Keywords | circadian, eating behavior rhythm, High-fat diet, mouse, obesity |
Abstract |
Abnormal meal timing, like skipping breakfast and late-night snacking, is associated with obesity in humans. Disruption of daily eating rhythms also contributes to obesity in mice. When fed high-fat diet, male C57BL/6J mice have disrupted eating behavior rhythms and they become obese. In contrast to obesity-prone C57BL/6J mice, some inbred strains of mice are resistant to high-fat diet-induced obesity. In this study, we sought to determine whether there are distinct effects of high-fat feeding on daily eating behavior rhythms in obesity-prone and obesity-resistant male mice. Male obesity-prone (C57BL/6J and 129X1/SvJ) and obesity-resistant (SWR/J and BALB/cJ) mice were fed low-fat diet or high-fat diet for 6 weeks. Consistent with previous studies, obesity-prone male mice gained more weight and adiposity during high-fat diet feeding than obesity-resistant male mice. The amplitude of the daily rhythm of eating behavior was markedly attenuated in male obesity-prone mice fed high-fat diet, but not in obesity-resistant males. In contrast, high-fat feeding did not differentially affect locomotor activity rhythms in obesity-prone and obesity-resistant male mice. Together, these data suggest that regulation of the daily rhythm of eating may underlie propensity to develop diet-induced obesity in male mice. |
Year of Publication |
2021
|
Journal |
American journal of physiology. Regulatory, integrative and comparative physiology
|
Date Published |
02/2021
|
ISSN Number |
1522-1490
|
DOI |
10.1152/ajpregu.00150.2020
|
Alternate Journal |
Am J Physiol Regul Integr Comp Physiol
|
PMID |
33626995
|
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