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Ceramides in Metabolism: Key Lipotoxic Players.
Citation | “Ceramides In Metabolism: Key Lipotoxic Players.”. Annual Review Of Physiology, pp. 303-330. . |
Center | Washington University in St Louis |
Author | Bhagirath Chaurasia, Scott A Summers |
Keywords | atherosclerosis, ceramides, diabetes, Dyslipidemia, Insulin resistance, obesity |
Abstract |
The global prevalence of metabolic diseases such as type 2 diabetes mellitus, steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past two decades. These obesity-fueled disorders result, in part, from the aberrant accumulation of harmful lipid metabolites in tissues not suited for lipid storage (e.g., the liver, vasculature, heart, and pancreatic beta-cells). Among the numerous lipid subtypes that accumulate, sphingolipids such as ceramides are particularly impactful, as they elicit the selective insulin resistance, dyslipidemia, and ultimately cell death that underlie nearly all metabolic disorders. This review summarizes recent findings on the regulatory pathways controlling ceramide production, the molecular mechanisms linking the lipids to these discrete pathogenic events, and exciting attempts to develop therapeutics to reduce ceramide levels to combat metabolic disease. |
Year of Publication |
2021
|
Journal |
Annual review of physiology
|
Volume |
83
|
Number of Pages |
303-330
|
Date Published |
12/2021
|
ISSN Number |
1545-1585
|
DOI |
10.1146/annurev-physiol-031620-093815
|
Alternate Journal |
Annu Rev Physiol
|
PMID |
33158378
|
PMCID |
PMC7905841
|
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