The genetic architecture of the human cerebral cortex.
| Citation | . “The Genetic Architecture Of The Human Cerebral Cortex.”. Science (New York, N.y.). |
| Center | UCSD-UCLA |
| Author | Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher R K Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo C P Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio A A Almeida, Dag Alnæs, Inge K Amlien, Micael Andersson, Tyler Ard, Nicola J Armstrong, Allison Ashley-Koch, Joshua R Atkins, Manon Bernard, Rachel M Brouwer, Elizabeth E L Buimer, Robin Bülow, Christian Bürger, Dara M Cannon, Mallar Chakravarty, Qiang Chen, Joshua W Cheung, Baptiste Couvy-Duchesne, Anders M Dale, Shareefa Dalvie, Tânia K de Araujo, Greig I de Zubicaray, Sonja M C de Zwarte, Anouk den Braber, Nhat Trung Doan, Katharina Dohm, Stefan Ehrlich, Hannah-Ruth Engelbrecht, Susanne Erk, Chun Chieh Fan, Iryna O Fedko, Sonya F Foley, Judith M Ford, Masaki Fukunaga, Melanie E Garrett, Tian Ge, Sudheer Giddaluru, Aaron L Goldman, Melissa J Green, Nynke A Groenewold, Dominik Grotegerd, Tiril P Gurholt, Boris A Gutman, Narelle K Hansell, Mathew A Harris, Marc B Harrison, Courtney C Haswell, Michael Hauser, Stefan Herms, Dirk J Heslenfeld, New Fei Ho, David Hoehn, Per Hoffmann, Laurena Holleran, Martine Hoogman, Jouke-Jan Hottenga, Masashi Ikeda, Deborah Janowitz, Iris E Jansen, Tianye Jia, Christiane Jockwitz, Ryota Kanai, Sherif Karama, Dalia Kasperaviciute, Tobias Kaufmann, Sinead Kelly, Masataka Kikuchi, Marieke Klein, Michael Knapp, Annchen R Knodt, Bernd Krämer, Max Lam, Thomas M Lancaster, Phil H Lee, Tristram A Lett, Lindsay B Lewis, Iscia Lopes-Cendes, Michelle Luciano, Fabio Macciardi, Andre F Marquand, Samuel R Mathias, Tracy R Melzer, Yuri Milaneschi, Nazanin Mirza-Schreiber, Jose C Moreira V, Thomas W Mühleisen, Bertram Müller-Myhsok, Pablo Najt, Soichiro Nakahara, Kwangsik Nho, Loes M Olde Loohuis, Dimitri Papadopoulos Orfanos, John F Pearson, Toni L Pitcher, Benno Pütz, Yann Quidé, Anjanibhargavi Ragothaman, Faisal M Rashid, William R Reay, Ronny Redlich, Céline S Reinbold, Jonathan Repple, Geneviève Richard, Brandalyn C Riedel, Shannon L Risacher, Cristiane S Rocha, Nina Roth Mota, Lauren Salminen, Arvin Saremi, Andrew J Saykin, Fenja Schlag, Lianne Schmaal, Peter R Schofield, Rodrigo Secolin, Chin Yang Shapland, Li Shen, Jean Shin, Elena Shumskaya, Ida E Sønderby, Emma Sprooten, Katherine E Tansey, Alexander Teumer, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Jessica A Turner, Anne Uhlmann, Costanza Ludovica Vallerga, Dennis van der Meer, Marjolein M J van Donkelaar, Liza van Eijk, Theo G M van Erp, Neeltje E M van Haren, Daan van Rooij, Marie-José van Tol, Jan H Veldink, Ellen Verhoef, Esther Walton, Mingyuan Wang, Yunpeng Wang, Joanna M Wardlaw, Wei Wen, Lars T Westlye, Christopher D Whelan, Stephanie H Witt, Katharina Wittfeld, Christiane Wolf, Thomas Wolfers, Jing Qin Wu, Clarissa L Yasuda, Dario Zaremba, Zuo Zhang, Marcel P Zwiers, Eric Artiges, Amelia A Assareh, Rosa Ayesa-Arriola, Aysenil Belger, Christine L Brandt, Gregory G Brown, Sven Cichon, Joanne E Curran, Gareth E Davies, Franziska Degenhardt, Michelle F Dennis, Bruno Dietsche, Srdjan Djurovic, Colin P Doherty, Ryan Espiritu, Daniel Garijo, Yolanda Gil, Penny A Gowland, Robert C Green, Alexander N Häusler, Walter Heindel, Beng-Choon Ho, Wolfgang U Hoffmann, Florian Holsboer, Georg Homuth, Norbert Hosten, Clifford R Jack, MiHyun Jang, Andreas Jansen, Nathan A Kimbrel, Knut Kolskår, Sanne Koops, Axel Krug, Kelvin O Lim, Jurjen J Luykx, Daniel H Mathalon, Karen A Mather, Venkata S Mattay, Sarah Matthews, Jaqueline Mayoral Van Son, Sarah C McEwen, Ingrid Melle, Derek W Morris, Bryon A Mueller, Matthias Nauck, Jan E Nordvik, Markus M Nöthen, Daniel S O'Leary, Nils Opel, Marie-Laure Paillère Martinot, Bruce Pike, Adrian Preda, Erin B Quinlan, Paul E Rasser, Varun Ratnakar, Simone Reppermund, Vidar M Steen, Paul A Tooney, Fábio R Torres, Dick J Veltman, James T Voyvodic, Robert Whelan, Tonya White, Hidenaga Yamamori, Hieab H H Adams, Joshua C Bis, Stéphanie Debette, Charles DeCarli, Myriam Fornage, Vilmundur Gudnason, Edith Hofer, Arfan Ikram, Lenore Launer, W T Longstreth, Oscar L Lopez, Bernard Mazoyer, Thomas H Mosley, Gennady Roshchupkin V, Claudia L Satizabal, Reinhold Schmidt, Sudha Seshadri, Qiong Yang, Alzheimer’s Disease Neuroimaging Initiative, CHARGE Consortium, EPIGEN Consortium, IMAGEN Consortium, SYS Consortium, Parkinson’s Progression Markers Initiative, Marina K M Alvim, David Ames, Tim J Anderson, Ole A Andreassen, Alejandro Arias-Vasquez, Mark E Bastin, Bernhard T Baune, Jean C Beckham, John Blangero, Dorret I Boomsma, Henry Brodaty, Han G Brunner, Randy L Buckner, Jan K Buitelaar, Juan R Bustillo, Wiepke Cahn, Murray J Cairns, Vince Calhoun, Vaughan J Carr, Xavier Caseras, Svenja Caspers, Gianpiero L Cavalleri, Fernando Cendes, Aiden Corvin, Benedicto Crespo-Facorro, John C Dalrymple-Alford, Udo Dannlowski, Eco J C de Geus, Ian J Deary, Norman Delanty, Chantal Depondt, Sylvane Desrivières, Gary Donohoe, Thomas Espeseth, Guillén Fernández, Simon E Fisher, Herta Flor, Andreas J Forstner, Clyde Francks, Barbara Franke, David C Glahn, Randy L Gollub, Hans J Grabe, Oliver Gruber, Asta K Håberg, Ahmad R Hariri, Catharina A Hartman, Ryota Hashimoto, Andreas Heinz, Frans A Henskens, Manon H J Hillegers, Pieter J Hoekstra, Avram J Holmes, Elliot Hong, William D Hopkins, Hilleke E Hulshoff Pol, Terry L Jernigan, Erik G Jönsson, René S Kahn, Martin A Kennedy, Tilo T J Kircher, Peter Kochunov, John B J Kwok, Stephanie Le Hellard, Carmel M Loughland, Nicholas G Martin, Jean-Luc Martinot, Colm McDonald, Katie L McMahon, Andreas Meyer-Lindenberg, Patricia T Michie, Rajendra A Morey, Bryan Mowry, Lars Nyberg, Jaap Oosterlaan, Roel A Ophoff, Christos Pantelis, Tomáš Paus, Zdenka Pausova, Brenda W J H Penninx, Tinca J C Polderman, Danielle Posthuma, Marcella Rietschel, Joshua L Roffman, Laura M Rowland, Perminder S Sachdev, Philipp G Sämann, Ulrich Schall, Gunter Schumann, Rodney J Scott, Kang Sim, Sanjay M Sisodiya, Jordan W Smoller, Iris E Sommer, Beate St Pourcain, Dan J Stein, Arthur W Toga, Julian N Trollor, Nic J A Van der Wee, Dennis van 't Ent, Henry Völzke, Henrik Walter, Bernd Weber, Daniel R Weinberger, Margaret J Wright, Juan Zhou, Jason L Stein, Paul M Thompson, Sarah E Medland, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium —Genetics working group |
| Abstract |
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder. |
| Year of Publication |
2020
|
| Journal |
Science (New York, N.Y.)
|
| Volume |
367
|
| Issue |
6484
|
| Date Published |
12/2020
|
| ISSN Number |
1095-9203
|
| DOI |
10.1126/science.aay6690
|
| Alternate Journal |
Science
|
| PMID |
32193296
|
| PMCID |
PMC7295264
|
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