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Membrane Capacitance from a Bioimpedance Approach: Associations with Insulin Resistance in Relatively Healthy Adults.

Citation
Barry, Valene Garr, et al. “Membrane Capacitance from a Bioimpedance Approach: Associations With Insulin Resistance in Relatively Healthy Adults”. 2020. Obesity (Silver Spring, Md.), vol. 28, no. 11, 2020, pp. 2184–2191.
Center University of Alabama at Birmingham
Author Valene Garr Barry, Courtney M Peterson, Barbara A Gower
Abstract

OBJECTIVE: This study aimed to determine whether higher membrane capacitance (C ), a bioelectrical measure of cell membrane function, is associated with insulin resistance (IR) and/or metabolic syndrome (MetS).

METHODS: Cross-sectional analyses were performed on 2,191 relatively healthy adults from the National Health and Nutrition Examination Survey. The C of those with low/no disease risk was compared with those with IR, MetS, or both IR and MetS using ANCOVA. The associations between C and related clinical measures were assessed with multiple linear regression.

RESULTS: Compared with those with low/no risk, women and men with IR (P < 0.001) and IR + MetS (P < 0.001) had higher C , whereas C was similar in women (P = 0.4526) and men (P = 0.1126) with MetS alone. Positive associations with C were seen with waist circumference (women and men standardized beta [STD-β] = 0.18, P < 0.0001) and fasting insulin (women STD-β = 0.15, P < 0.0001; men STD-β = 0.12, P < 0.0001).

CONCLUSIONS: Higher C was associated with IR in relatively healthy adults. In the absence of IR, higher C was not associated with MetS as defined by its clinical diagnostic criteria. This study suggests that with further investigation, C may be a potential tool to detect IR-related cell membrane dysfunction.

Year of Publication
2020
Journal
Obesity (Silver Spring, Md.)
Volume
28
Issue
11
Number of Pages
2184-2191
Date Published
11/2020
ISSN Number
1930-739X
DOI
10.1002/oby.22977
Alternate Journal
Obesity (Silver Spring)
PMID
33012132
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