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Associations Between the Time in Hypoglycemia and Hypoglycemia Awareness Status in Type 1 Diabetes Patients Using Continuous Glucose Monitoring Systems.
Citation | “Associations Between The Time In Hypoglycemia And Hypoglycemia Awareness Status In Type 1 Diabetes Patients Using Continuous Glucose Monitoring Systems.”. Diabetes Technology & Therapeutics, pp. 787-793. . |
Center | Washington University in St Louis |
Author | Yu Kuei Lin, Danielle Groat, Owen Chan, Man Hung, Anu Sharma, Michael W Varner, Ramkiran Gouripeddi, Julio C Facelli, Simon J Fisher |
Keywords | Continuous glucose monitoring, hypoglycemia, Impaired awareness of hypoglycemia, type 1 diabetes |
Abstract |
Continuous glucose monitoring (CGM) systems help reduce hypoglycemia in patients with type 1 diabetes (T1D). It remains unclear whether T1D patients with impaired awareness of hypoglycemia (IAH) continue to develop more hypoglycemia than those with normal hypoglycemia awareness (NA) despite CGM use. For this cross-sectional observational study, 99 T1D patients using real-time CGMs for ≥86% of time were recruited. Fifty and 49 patients were found to have NA and IAH (based on the Clarke questionnaire), respectively. Two-week CGM hypoglycemia data were collected. IAH was associated with greater percentages of CGM values <70 and <54 mg/dL ( = 0.012, = 0.004) compared to NA. Clarke scores correlated positively with the percentage of CGM values <70 and <54 mg/dL ( = 0.013, = 0.004). IAH was also related to more events with glucose <70 and <54 mg/dL determined either with at ≥1 time point ( = 0.048, = 0.003) or lasting ≥20 min ( = 0.016, = 0.004). IAH patients presented with more day-time events with glucose <54 mg/dL ( = 0.015), nocturnal events with glucose levels <70 and <54 mg/dL ( = 0.009, = 0.007) and longer day-time event duration with glucose levels <70 and <54 mg/dL ( < 0.001, = 0.006), respectively. T1D patients with IAH continue to experience more hypoglycemia despite dedicated CGM use. |
Year of Publication |
2020
|
Journal |
Diabetes technology & therapeutics
|
Volume |
22
|
Issue |
11
|
Number of Pages |
787-793
|
Date Published |
12/2020
|
ISSN Number |
1557-8593
|
DOI |
10.1089/dia.2020.0016
|
Alternate Journal |
Diabetes Technol Ther
|
PMID |
32267773
|
PMCID |
PMC7699009
|
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