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- Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI.
Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI.
Citation | “Clarifying The Function Of Genes At The Chromosome 16P13 Locus In Type 1 Diabetes: Clec16A And Dexi.”. Genes And Immunity, pp. 79-82. . |
Center | University of Michigan |
Author | Morgan A Gingerich, Vaibhav Sidarala, Scott A Soleimanpour |
Abstract |
More than a decade after the discovery of a novel type 1 diabetes risk locus on chromosome 16p13, there remains complexity and controversy over the specific gene(s) that regulate diabetes pathogenesis. A new study by Nieves-Bonilla et al. shows that one of these genes, DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus influences diabetes risk. |
Year of Publication |
2020
|
Journal |
Genes and immunity
|
Volume |
21
|
Issue |
2
|
Number of Pages |
79-82
|
Date Published |
12/2020
|
ISSN Number |
1476-5470
|
DOI |
10.1038/s41435-019-0087-7
|
Alternate Journal |
Genes Immun.
|
PMID |
31570815
|
PMCID |
PMC7108966
|
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