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African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.
Citation | “African Ancestry-Specific Alleles And Kidney Disease Risk In Hispanics/Latinos.”. Journal Of The American Society Of Nephrology : Jasn, pp. 915-922. . |
Center | UCSD-UCLA |
Author | Holly J Kramer, Adrienne M Stilp, Cathy C Laurie, Alex P Reiner, James Lash, Martha L Daviglus, Sylvia E Rosas, Ana C Ricardo, Bamidele O Tayo, Michael F Flessner, Kathleen F Kerr, Carmen Peralta, Ramon Durazo-Arvizu, Matt Conomos, Timothy Thornton, Jerome Rotter, Kent D Taylor, Jainwen Cai, John Eckfeldt, Han Chen, George Papanicolau, Nora Franceschini |
Keywords | African Ancestry, Hispanic, Latino, albuminuria, Chronic kidney disease, genetic variants |
Abstract |
African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We examined the association of CKD measures with African ancestry-specific alleles that were directly genotyped and sickle cell trait (hemoglobin subunit gene [] variant) on the basis of imputation in 12,226 adult Hispanics/Latinos grouped according to Caribbean or Mainland background. We also performed an unbiased genome-wide association scan of urine albumin-to-creatinine ratios. Overall, 41.4% of participants were male, 44.6% of participants had a Caribbean background, and the mean age of all participants was 46.1 years. The Caribbean background group, compared with the Mainland background group, had a higher frequency of two alleles (1.0% versus 0.1%) and the variant (2.0% versus 0.7%). In the Caribbean background group, presence of alleles (2 versus 0/1 copies) or the variant (1 versus 0 copies) were significantly associated with albuminuria (odds ratio [OR], 3.2; 95% confidence interval [95% CI], 1.7 to 6.1; and OR, 2.6; 95% CI, 1.8 to 3.8, respectively) and albuminuria and/or eGFR<60 ml/min per 1.73 m (OR, 2.9; 95% CI, 1.5 to 5.4; and OR, 2.4; 95% CI, 1.7 to 3.5, respectively). The urine albumin-to-creatinine ratio genome-wide association scan identified associations with the variant among all participants, with the strongest association in the Caribbean background group (=3.1×10 versus =9.3×10 for the Mainland background group). In conclusion, African-specific alleles associate with CKD in Hispanics/Latinos, but allele frequency varies by Hispanic/Latino background/ancestry. |
Year of Publication |
2017
|
Journal |
Journal of the American Society of Nephrology : JASN
|
Volume |
28
|
Issue |
3
|
Number of Pages |
915-922
|
Date Published |
03/2017
|
ISSN Number |
1533-3450
|
DOI |
10.1681/ASN.2016030357
|
Alternate Journal |
J. Am. Soc. Nephrol.
|
PMID |
27650483
|
PMCID |
PMC5328161
|
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