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The initiation of metabolic inflammation in childhood obesity.

Citation
Singer, K., and C. N. Lumeng. “The Initiation Of Metabolic Inflammation In Childhood Obesity.”. The Journal Of Clinical Investigation, pp. 65-73.
Center University of Michigan
Author Kanakadurga Singer, Carey N Lumeng
Abstract

An understanding of the events that initiate metabolic inflammation (metainflammation) can support the identification of targets for preventing metabolic disease and its negative effects on health. There is ample evidence demonstrating that the initiating events in obesity-induced inflammation start early in childhood. This has significant implications on our understanding of how early life events in childhood influence adult disease. In this Review we frame the initiating events of metainflammation in the context of child development and discuss what this reveals about the mechanisms by which this unique form of chronic inflammation is initiated and sustained into adulthood.

Year of Publication
2017
Journal
The Journal of clinical investigation
Volume
127
Issue
1
Number of Pages
65-73
Date Published
12/2017
ISSN Number
1558-8238
DOI
10.1172/JCI88882
Alternate Journal
J. Clin. Invest.
PMID
28045405
PMCID
PMC5199687
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