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Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease.

Citation
Parks, E., et al. “Out Of The Frying Pan: Dietary Saturated Fat Influences Nonalcoholic Fatty Liver Disease.”. The Journal Of Clinical Investigation, pp. 454-456.
Center Albert Einstein College of Medicine
Author Elizabeth Parks, Hannele Yki-Järvinen, Meredith Hawkins
Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.

Year of Publication
2017
Journal
The Journal of clinical investigation
Volume
127
Issue
2
Number of Pages
454-456
Date Published
02/2017
ISSN Number
1558-8238
DOI
10.1172/JCI92407
Alternate Journal
J. Clin. Invest.
PMID
28112684
PMCID
PMC5272176
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