Skip to main content

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases.

Citation
Laakso, M., et al. “The Metabolic Syndrome In Men Study: A Resource For Studies Of Metabolic And Cardiovascular Diseases.”. Journal Of Lipid Research, pp. 481-493.
Center University of Michigan
Author Markku Laakso, Johanna Kuusisto, Alena Stancáková, Teemu Kuulasmaa, Päivi Pajukanta, Aldons J Lusis, Francis S Collins, Karen L Mohlke, Michael Boehnke
Keywords METSIM, cardiovascular risk factors, coronary artery disease, Metabolic disease, type 2 diabetes
Abstract

The Metabolic Syndrome in Men (METSIM) study is a population-based study including 10,197 Finnish men examined in 2005-2010. The aim of the study is to investigate nongenetic and genetic factors associated with the risk of T2D and CVD, and with cardiovascular risk factors. The protocol includes a detailed phenotyping of the participants, an oral glucose tolerance test, fasting laboratory measurements including proton NMR measurements, mass spectometry metabolomics, adipose tissue biopsies from 1,400 participants, and a stool sample. In our ongoing follow-up study, we have, to date, reexamined 6,496 participants. Extensive genotyping and exome sequencing have been performed for essentially all METSIM participants, and >2,000 METSIM participants have been whole-genome sequenced. We have identified several nongenetic markers associated with the development of diabetes and cardiovascular events, and participated in several genetic association studies to identify gene variants associated with diabetes, hyperglycemia, and cardiovascular risk factors. The generation of a phenotype and genotype resource in the METSIM study allows us to proceed toward a "systems genetics" approach, which includes statistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein, or metabolite levels, to provide a global view of the molecular architecture of complex traits.

Year of Publication
2017
Journal
Journal of lipid research
Volume
58
Issue
3
Number of Pages
481-493
Date Published
12/2017
ISSN Number
1539-7262
DOI
10.1194/jlr.O072629
Alternate Journal
J. Lipid Res.
PMID
28119442
PMCID
PMC5335588
Download citation