Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes.
| Citation | . “Glucose Driven Changes In Beta Cell Identity Are Important For Function And Possibly Autoimmune Vulnerability During The Progression Of Type 1 Diabetes.”. Frontiers In Genetics, p. 2. |
| Center | Joslin Diabetes Center |
| Author | Gordon C Weir, Susan Bonner-Weir |
| Keywords | autoimmunity, beta-cell biology, Beta-cell function, beta-cell identity, type 1 diabetes |
| Abstract |
This commentary explores the hypothesis that when autoimmunity leads to a fall of beta cell mass during the progression of type 1 diabetes (T1D), rising glucose levels cause major changes in beta cell identity. This then leads to profound changes in secretory function and less well-understood changes in beta cell susceptibility to autoimmune destruction, which may influence of rate of progression of beta cell killing. |
| Year of Publication |
2017
|
| Journal |
Frontiers in genetics
|
| Volume |
8
|
| Number of Pages |
2
|
| Date Published |
12/2017
|
| ISSN Number |
1664-8021
|
| DOI |
10.3389/fgene.2017.00002
|
| Alternate Journal |
Front Genet
|
| PMID |
28174593
|
| PMCID |
PMC5258704
|
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