Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?
| Citation | . “Excess Bmi In Childhood: A Modifiable Risk Factor For Type 1 Diabetes Development?”. Diabetes Care, pp. 698-701. |
| Center | Indiana University |
| Multicenter |
Multicenter
|
| Author | Christine Therese Ferrara, Susan Michelle Geyer, Yuk-Fun Liu, Carmella Evans-Molina, Ingrid M Libman, Rachel Besser, Dorothy J Becker, Henry Rodriguez, Antoinette Moran, Stephen E Gitelman, Maria J Redondo, Type 1 Diabetes TrialNet Study Group |
| Abstract |
OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age. |
| Year of Publication |
2017
|
| Journal |
Diabetes care
|
| Volume |
40
|
| Issue |
5
|
| Number of Pages |
698-701
|
| Date Published |
12/2017
|
| ISSN Number |
1935-5548
|
| DOI |
10.2337/dc16-2331
|
| Alternate Journal |
Diabetes Care
|
| PMID |
28202550
|
| PMCID |
PMC5399656
|
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