Intracellular calcium release channels: an update.
| Citation | . “Intracellular Calcium Release Channels: An Update.”. The Journal Of Physiology, pp. 3041-3051. |
| Center | Albert Einstein College of Medicine |
| Author | Gaetano Santulli, Ryutaro Nakashima, Qi Yuan, Andrew R Marks |
| Keywords | Calcium, diabetes mellitus, Heart failure, hypertension, IP3R, Intracellular calcium release channels, RyR, excitation-contraction coupling |
| Abstract |
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP Rs) are calcium (Ca ) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus. |
| Year of Publication |
2017
|
| Journal |
The Journal of physiology
|
| Volume |
595
|
| Issue |
10
|
| Number of Pages |
3041-3051
|
| Date Published |
12/2017
|
| ISSN Number |
1469-7793
|
| DOI |
10.1113/JP272781
|
| Alternate Journal |
J. Physiol. (Lond.)
|
| PMID |
28303572
|
| PMCID |
PMC5430224
|
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