Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
| Citation | . “Regulatory T Cells In Skin Facilitate Epithelial Stem Cell Differentiation.”. Cell, pp. 1119-1129.e11. |
| Author | Niwa Ali, Bahar Zirak, Robert Sanchez Rodriguez, Mariela L Pauli, Hong-An Truong, Kevin Lai, Richard Ahn, Kaitlin Corbin, Margaret M Lowe, Tiffany C Scharschmidt, Keyon Taravati, Madeleine R Tan, Roberto R Ricardo-Gonzalez, Audrey Nosbaum, Marta Bertolini, Wilson Liao, Frank O Nestle, Ralf Paus, George Cotsarelis, Abul K Abbas, Michael D Rosenblum |
| Keywords | Jagged 1, Notch, alopecia areata, hair, hair follicle stem cell, hair regeneration, regulatory T cell, skin |
| Abstract |
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of T and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs. |
| Year of Publication |
2017
|
| Journal |
Cell
|
| Volume |
169
|
| Issue |
6
|
| Number of Pages |
1119-1129.e11
|
| Date Published |
06/2017
|
| ISSN Number |
1097-4172
|
| DOI |
10.1016/j.cell.2017.05.002
|
| Alternate Journal |
Cell
|
| PMID |
28552347
|
| PMCID |
PMC5504703
|
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