Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
| Citation | . “Common, Low-Frequency, And Rare Genetic Variants Associated With Lipoprotein Subclasses And Triglyceride Measures In Finnish Men From The Metsim Study.”. Plos Genetics, p. e1007079. |
| Center | University of Michigan |
| Author | James P Davis, Jeroen R Huyghe, Adam E Locke, Anne U Jackson, Xueling Sim, Heather M Stringham, Tanya M Teslovich, Ryan P Welch, Christian Fuchsberger, Narisu Narisu, Peter S Chines, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Johanna Kuusisto, Francis S Collins, Markku Laakso, Michael Boehnke, Karen L Mohlke |
| Abstract |
Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005 |
| Year of Publication |
2017
|
| Journal |
PLoS genetics
|
| Volume |
13
|
| Issue |
10
|
| Number of Pages |
e1007079
|
| Date Published |
10/2017
|
| ISSN Number |
1553-7404
|
| DOI |
10.1371/journal.pgen.1007079
|
| Alternate Journal |
PLoS Genet.
|
| PMID |
29084231
|
| PMCID |
PMC5679656
|
| Download citation |