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- Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.
Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.
Citation | “Review Of Methods For Measuring Β-Cell Function: Design Considerations From The Restoring Insulin Secretion (Rise) Consortium.”. Diabetes, Obesity & Metabolism, pp. 14-24. . |
Center | Indiana University University of Washington |
Multicenter |
Multicenter
|
Author | Tamara S Hannon, Steven E Kahn, Kristina M Utzschneider, Thomas A Buchanan, Kristen J Nadeau, Philip S Zeitler, David A Ehrmann, Silva A Arslanian, Sonia Caprio, Sharon L Edelstein, Peter J Savage, Kieren J Mather, RISE Consortium |
Keywords | glucose metabolism, Insulin resistance, insulin secretion, type 2 diabetes, β cell |
Abstract |
The Restoring Insulin Secretion (RISE) study was initiated to evaluate interventions to slow or reverse the progression of β-cell failure in type 2 diabetes (T2D). To design the RISE study, we undertook an evaluation of methods for measurement of β-cell function and changes in β-cell function in response to interventions. In the present paper, we review approaches for measurement of β-cell function, focusing on methodologic and feasibility considerations. Methodologic considerations included: (1) the utility of each technique for evaluating key aspects of β-cell function (first- and second-phase insulin secretion, maximum insulin secretion, glucose sensitivity, incretin effects) and (2) tactics for incorporating a measurement of insulin sensitivity in order to adjust insulin secretion measures for insulin sensitivity appropriately. Of particular concern were the capacity to measure β-cell function accurately in those with poor function, as is seen in established T2D, and the capacity of each method for demonstrating treatment-induced changes in β-cell function. Feasibility considerations included: staff burden, including time and required methodological expertise; participant burden, including time and number of study visits; and ease of standardizing methods across a multicentre consortium. After this evaluation, we selected a 2-day measurement procedure, combining a 3-hour 75-g oral glucose tolerance test and a 2-stage hyperglycaemic clamp procedure, augmented with arginine. |
Year of Publication |
2018
|
Journal |
Diabetes, obesity & metabolism
|
Volume |
20
|
Issue |
1
|
Number of Pages |
14-24
|
Date Published |
12/2018
|
ISSN Number |
1463-1326
|
DOI |
10.1111/dom.13005
|
Alternate Journal |
Diabetes Obes Metab
|
PMID |
28493515
|
PMCID |
PMC6095472
|
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