Diet quality, inflammation, and the ankle brachial index in adults with or without cardiometabolic conditions.
Citation | Mattei, Josiemer, et al. “Diet Quality, Inflammation, and the Ankle Brachial Index in Adults With or Without Cardiometabolic Conditions”. 2018. Clinical Nutrition (Edinburgh, Scotland), vol. 37, no. 4, 2018, pp. 1332–1339. |
Center | Albert Einstein College of Medicine |
Author | Josiemer Mattei, Daniela Sotres-Alvarez, Marc Gellman, Sheila F Castañeda, Frank B Hu, Katherine L Tucker, Anna Maria Siega-Riz, Robert C Kaplan |
Keywords | Ankle brachial blood pressure index, Diet quality, HCHS/SOL, inflammation, Peripheral arterial disease, Subclinical vascular disease |
Abstract |
BACKGROUND & AIMS: Diet quality may influence non-traditional cardiovascular disease (CVD) risk factors - namely, C-reactive protein (CRP) and the ankle-brachial index (ABI). Pre-existing traditional cardiometabolic conditions may confound this association. We aimed to determine whether diet quality was associated with high-risk CRP or ABI, independently from traditional cardiometabolic risk factors. METHODS: Baseline data were analyzed from US-Hispanics/Latinos aged 18-74 y without previously-diagnosed CVD participating in the population-based Hispanic Community Health Study/Study of Latinos cohort. Included were 14,623 participants with CRP data, and 7892 participants (≥45 y) with ABI data. Diet quality was measured with the Alternate Healthy Eating Index (AHEI). RESULTS: Nearly 35% of Hispanics/Latinos had high-risk CRP concentration and 6.3% had high-risk ABI (peripheral artery disease (PAD): 4.2%; arterial stiffness: 2.1%). After adjusting for sociodemographic and lifestyle factors, diabetes, hypertension, hypercholesterolemia, and obesity, the odds (95% confidence interval) of having high-risk ABI were 37% (5, 44%) lower per 10-unit increase in AHEI (p = 0.018). The association was marginally significant for PAD (0.77 (0.58, 1.00); p = 0.05), and non-significant for arterial stiffness (p = 0.16). Each 10-unit increase in AHEI was associated with 21% (10, 30%) lower odds of high-risk CRP (p = 0.0002) after similar adjustments. There were no significant interactions between AHEI and age, sex, ethnicity, smoking, or pre-existing cardiometabolic conditions for associations with ABI. The association between AHEI and high-risk CRP was stronger for those with diabetes (p-interaction < 0.0001), obesity (p-interaction = 0.005), or ages 45-74 y (p-interaction = 0.011). CONCLUSIONS: Higher diet quality is associated with lower inflammation and less adverse ABI among Hispanics/Latinos, independently from traditional cardiometabolic risk factors. |
Year of Publication |
2018
|
Journal |
Clinical nutrition (Edinburgh, Scotland)
|
Volume |
37
|
Issue |
4
|
Number of Pages |
1332-1339
|
Date Published |
12/2018
|
ISSN Number |
1532-1983
|
DOI |
10.1016/j.clnu.2017.06.003
|
Alternate Journal |
Clin Nutr
|
PMID |
28666597
|
PMCID |
PMC5722708
|
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