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Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.
Citation | “Pancreatic Β Cell Regeneration As A Possible Therapy For Diabetes.”. Cell Metabolism, pp. 57-67. . |
Center | Boston Area Joslin Diabetes Center |
Multicenter |
Multicenter
|
Author | Cristina Aguayo-Mazzucato, Susan Bonner-Weir |
Keywords | diabetes, neogenesis, pancreatic beta cells, replication, Transdifferentiation |
Abstract |
Diabetes is the result of having inadequate supply of functional insulin-producing β cells. Two possible approaches for replenishing the β cells are: (1) replacement by transplanting cadaveric islets or β cells derived from human embryonic stem cells/induced pluripotent stem cells and (2) induction of endogenous regeneration. This review focuses on endogenous regeneration, which can follow two pathways: enhanced replication of existing β cells and formation of new β cells from cells not expressing insulin, either by conversion from a differentiated cell type (transdifferentiation) or differentiation from progenitors (neogenesis). Exciting progress on both pathways suggest that regeneration may have therapeutic promise. |
Year of Publication |
2018
|
Journal |
Cell metabolism
|
Volume |
27
|
Issue |
1
|
Number of Pages |
57-67
|
Date Published |
12/2018
|
ISSN Number |
1932-7420
|
DOI |
10.1016/j.cmet.2017.08.007
|
Alternate Journal |
Cell Metab.
|
PMID |
28889951
|
PMCID |
PMC5762410
|
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