- Home
- Featured Publications
- Center Publications
- Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study.
Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study.
Citation | “Physical Function Following A Long-Term Lifestyle Intervention Among Middle Aged And Older Adults With Type 2 Diabetes: The Look Ahead Study.”. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences, pp. 1552-1559. . |
Center | Joslin Diabetes Center University of Alabama at Birmingham University of Washington |
Multicenter |
Multicenter
|
Author | Denise K Houston, Rebecca H Neiberg, Michael E Miller, James O Hill, John M Jakicic, Karen C Johnson, Edward W Gregg, Van S Hubbard, Xavier Pi-Sunyer, Jack Rejeski, Rena R Wing, John P Bantle, Elizabeth Beale, Robert I Berkowitz, Maria Cassidy-Begay, Jeanne M Clark, Mace Coday, Linda M Delahanty, Gareth Dutton, Caitlin Egan, John P Foreyt, Frank L Greenway, Helen P Hazuda, Andrea Hergenroeder, Edward S Horton, Robert W Jeffery, Steven E Kahn, Anne Kure, William C Knowler, Cora E Lewis, Corby K Martin, Sara Michaels, Maria G Montez, David M Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A Wadden, Karen White, Susan Z Yanovski, Ping Zhang, Stephen B Kritchevsky |
Abstract |
Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods: Overweight and obese (body mass index ≥ 25 kg/m2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783). Results: Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p = .002, and 0.023 [0.012 to 0.034] m/sec, p < .0001, respectively) and higher SPPBexp scores (0.037 [0.011 to 0.063], p = .005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPBexp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p = .01). Conclusions: An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes. ClinicalTrials.gov Identifier: NCT00017953. |
Year of Publication |
2018
|
Journal |
The journals of gerontology. Series A, Biological sciences and medical sciences
|
Volume |
73
|
Issue |
11
|
Number of Pages |
1552-1559
|
Date Published |
12/2018
|
ISSN Number |
1758-535X
|
DOI |
10.1093/gerona/glx204
|
Alternate Journal |
J. Gerontol. A Biol. Sci. Med. Sci.
|
PMID |
29053861
|
PMCID |
PMC6175031
|
Download citation |