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Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Citation
Corbit, K. C., et al. “Adipocyte Jak2 Regulates Hepatic Insulin Sensitivity Independently Of Body Composition, Liver Lipid Content, And Hepatic Insulin Signaling.”. Diabetes, pp. 208-221.
Center Yale University
Multicenter
Multicenter
Author Kevin C Corbit, João Paulo G Camporez, Lia R Edmunds, Jennifer L Tran, Nicholas B Vera, Derek M Erion, Rahul C Deo, Rachel J Perry, Gerald I Shulman, Michael J Jurczak, Ethan J Weiss
Abstract

Disruption of hepatocyte growth hormone (GH) signaling through disruption of (JAK2L) leads to fatty liver. Previously, we demonstrated that development of fatty liver depends on adipocyte GH signaling. We sought to determine the individual roles of hepatocyte and adipocyte on whole-body and tissue insulin sensitivity and liver metabolism. On chow, JAK2L mice had hepatic steatosis and severe whole-body and hepatic insulin resistance. However, concomitant deletion of in hepatocytes and adipocytes (JAK2LA) completely normalized insulin sensitivity while reducing liver lipid content. On high-fat diet, JAK2L mice had hepatic steatosis and insulin resistance despite protection from diet-induced obesity. JAK2LA mice had higher liver lipid content and no protection from obesity but retained exquisite hepatic insulin sensitivity. AKT activity was selectively attenuated in JAK2L adipose tissue, whereas hepatic insulin signaling remained intact despite profound hepatic insulin resistance. Therefore, JAK2 in adipose tissue is epistatic to liver with regard to insulin sensitivity and responsiveness, despite fatty liver and obesity. However, hepatocyte autonomous JAK2 signaling regulates liver lipid deposition under conditions of excess dietary fat. This work demonstrates how various tissues integrate JAK2 signals to regulate insulin/glucose and lipid metabolism.

Year of Publication
2018
Journal
Diabetes
Volume
67
Issue
2
Number of Pages
208-221
Date Published
12/2018
ISSN Number
1939-327X
DOI
10.2337/db17-0524
Alternate Journal
Diabetes
PMID
29203511
PMCID
PMC5780061
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