Using Drosophila to Understand Biochemical and Behavioral Responses to Exercise.

The development of endurance exercise paradigms in Drosophila has facilitated study of genetic factors that control individual response to exercise. Recent work in Drosophila has demonstrated that activation of octopaminergic neurons is alone sufficient to confer exercise adaptations to sedentary flies. These results suggest that adrenergic activity is both necessary and sufficient to promote endurance exercise adaptations.