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Management of Hypertension and High Low-Density Lipoprotein in Pediatric Type 1 Diabetes.

Citation
Katz, M. L., et al. “Management Of Hypertension And High Low-Density Lipoprotein In Pediatric Type 1 Diabetes.”. The Journal Of Pediatrics, pp. 140-146.e12.
Center Joslin Diabetes Center
Author Michelle L Katz, Zijing Guo, Lori M Laffel
Keywords anti-hypertensive, cholesterol, lipid-lowering
Abstract

OBJECTIVE: To evaluate hypertension and hyperlipidemia management patterns in youth with type 1 diabetes and to assess perceived effectiveness of management strategies and barriers to management.

STUDY DESIGN: An electronic survey, including clinical scenarios, fielded to pediatric providers (members of the American Diabetes Association Diabetes in Youth Interest Group, Pediatric Endocrine Society, or T1D Exchange).

RESULTS: Respondents (N = 207, 86% MDs, 68% female) were practicing clinicians for youth with type 1 diabetes. As an initial recommendation, the overwhelming majority of respondents (83%-99%) endorsed lifestyle and nonmedical recommendations (eg, improve glycemic control) for hypertension and hyperlipidemia. Yet, few (6%-17%) reported these recommendations as effective. Many respondents (57%) reported referring to another specialist for hypertension, whereas few (8%) reported referring to another specialist for hyperlipidemia management. Approximately one-fifth (21%) of respondents never initiate antihypertensive medications, whereas only 8% never initiate lipid-lowering medication. Among prescribers, the majority of respondents only started antihypertensive or lipid-lowering medications after persistent elevations and in the setting of either ineffective lifestyle or nonmedical interventions or additional cardiovascular risk factors. More than two-thirds of respondents endorsed medications as often effective for hypertension and hyperlipidemia (68% and 69%, respectively).

CONCLUSIONS: Pediatric diabetes providers commonly defer prescribing antihypertensive and lipid-lowering medications until nonmedication interventions have been ineffective. Most providers describe medications, but not lifestyle interventions, as often effective. Efforts to align clinical practice with clinical guidelines are needed.

Year of Publication
2018
Journal
The Journal of pediatrics
Volume
197
Number of Pages
140-146.e12
Date Published
12/2018
ISSN Number
1097-6833
DOI
10.1016/j.jpeds.2017.11.059
Alternate Journal
J. Pediatr.
PMID
29395184
PMCID
PMC6013061
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