Sex differences underlying pancreatic islet biology and its dysfunction.
| Citation | . “Sex Differences Underlying Pancreatic Islet Biology And Its Dysfunction.”. Molecular Metabolism, pp. 82-91. |
| Center | Joslin Diabetes Center University of Alabama at Birmingham |
| Multicenter |
Multicenter
|
| Author | Maureen Gannon, Rohit N Kulkarni, Hubert M Tse, Franck Mauvais-Jarvis |
| Keywords | diabetes, Gender differences, Immune cells, islet, Sex differences, α-Cell, β-Cell |
| Abstract |
BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes. |
| Year of Publication |
2018
|
| Journal |
Molecular metabolism
|
| Volume |
15
|
| Number of Pages |
82-91
|
| Date Published |
12/2018
|
| ISSN Number |
2212-8778
|
| DOI |
10.1016/j.molmet.2018.05.017
|
| Alternate Journal |
Mol Metab
|
| PMID |
29891438
|
| PMCID |
PMC6066785
|
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