iPLAβ and its role in male fertility, neurological disorders, metabolic disorders, and inflammation.

The Ca-independent phospholipases, designated as group VI iPLAs, also referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and η forms of the enzyme. The iPLAs are ubiquitously expressed, share a consensus GXSXG catalytic motif, and exhibit organelle/cell-specific localization. Among the iPLAs, iPLAβ has received wide attention as it is recognized to be involved in membrane remodeling, cell proliferation, cell death, and signal transduction. Ongoing studies implicate participation of iPLAβ in a variety of disease processes including cancer, cardiovascular abnormalities, glaucoma, and peridonditis. This review will focus on iPLAβ and its links to male fertility, neurological disorders, metabolic disorders, and inflammation.