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[title] => [Franz M. Matschinsky, M.D.]
[body] => [<div class="field field-type-image field-field-people-image"><div class="field-label">People Image: </div><div class="field-items"><div class="field-item"><img src="http://diabetescenters.org/files/fmatschinsky.jpg" alt="fmatschinsky.jpg" title="fmatschinsky.jpg" width="193" height="212" /></div></div></div><div class="field field-type-text field-field-center-name"><div class="field-label">Center Name: </div><div class="field-items"><div class="field-item">DERC - University of Pennsylvania</div></div></div><div class="field field-type-text field-field-core"><div class="field-label">Core List: </div><div class="field-items"><div class="field-item">DERC - U Pennsylvania Islet Cell Biology Core</div></div></div><div class="field field-type-text field-field-phone-number"><div class="field-label">Phone Number: </div><div class="field-items"><div class="field-item">(215)-898-4368</div></div></div><div class="field field-type-text field-field-people-details"><div class="field-label">People Details: </div><div class="field-items"><div class="field-item"><p><strong>DESCRIPTION OF RESEARCH INTERESTS: </strong></p>
<p>The laboratory investigates the biochemical basis of fuel sensing by pancreatic islet cells, in particular the molecular mechanisms of amino acid, fatty acid and glucose stimulated insulin release. The "glucokinase glucose sensor concept" is central to all these studies. The endocrine, neural and pharmacological modification of fuel stimulated insulin release is another focus of the laboratory. The molecular genetic basis of glucokinase linked hypo-and hyperglycemia syndromes which are caused by more than 200 mutations of the glucokinase (GK) gene in man continue to be a topic of intense interest. A newly discovered class of pharmacological agents called GK activators (GKAs) are studied with recombinant human wildtype and mutant GK, with intact pancreatic islet cells and in the intact animal to assess the therapeutic potential of these agents for the treatment of type II and perhaps type I diabetes.</p>
<p><a href="http://www.med.upenn.edu/idom/derc/cores_cellbio_staff.html">More</a></p>
</div></div></div><div class="field field-type-text field-field-center-title"><div class="field-label">center_title: </div><div class="field-items"><div class="field-item">Proffesor of Biochemistry and Biophysics ,Director of Islet Biology Core </div></div></div><div class="field field-type-text field-field-address"><div class="field-label">Address: </div><div class="field-items"><div class="field-item">University of Pennsylvania 605 CRB 15 Curie Boulevard Philadelphia, PA 19104-6015</div></div></div>]
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<p>The laboratory investigates the biochemical basis of fuel sensing by pancreatic islet cells, in particular the molecular mechanisms of amino acid, fatty acid and glucose stimulated insulin release. The "glucokinase glucose sensor concept" is central to all these studies. The endocrine, neural and pharmacological modification of fuel stimulated insulin release is another focus of the laboratory. The molecular genetic basis of glucokinase linked hypo-and hyperglycemia syndromes which are caused by more than 200 mutations of the glucokinase (GK) gene in man continue to be a topic of intense interest. A newly discovered class of pharmacological agents called GK activators (GKAs) are studied with recombinant human wildtype and mutant GK, with intact pancreatic islet cells and in the intact animal to assess the therapeutic potential of these agents for the treatment of type II and perhaps type I diabetes.</p>
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<p><a href="http://www.med.upenn.edu/idom/derc/cores_cellbio_staff.html">More</a></p>
</div></div></div><div class="field field-type-text field-field-center-title"><div class="field-label">center_title: </div><div class="field-items"><div class="field-item">Proffesor of Biochemistry and Biophysics ,Director of Islet Biology Core </div></div></div><div class="field field-type-text field-field-address"><div class="field-label">Address: </div><div class="field-items"><div class="field-item">University of Pennsylvania 605 CRB 15 Curie Boulevard Philadelphia, PA 19104-6015</div></div></div>]
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