Joslin DERC is part of Joslin Diabetes Center. Since its founding in 1898, Joslin Diabetes Center has constantly evolved to meet the ever-changing challenges of diabetes. Joslin Diabetes Center is an institution on the front lines of the world epidemic of diabetes, leading the battle to conquer diabetes in all of its forms through cutting-edge research and innovative approaches to clinical care and education. It is located in the Longwood Medical and Academic Area in Boston, Massachusetts. Among the Harvard Medical School Affiliated institutions, Joslin is unique in its sole focus on diabetes. Joslin has the world’s largest team of board-certified physicians treating diabetes and its complications, as well as the largest staff of Certified Diabetes Educators anywhere in the world. Since its inception, Joslin has focused on aggressive, comprehensive care of the patient. Over 23,000 active patients receive specialty care for their eyes, hearts, kidneys, pregnancies and feet. Joslin supports the world’s largest diabetes research team with more than 40 faculty level investigators for a total of more than 300 researchers. Joslin has 25 clinical care affiliates in the US and two internationally, where an additional 79,000 patients with diabetes are trained to take care of their diabetes.

The primary aim of the Joslin Diabetes and Endocrinology Research Center (DERC) is to provide a stable framework on which to conduct multi-disciplinary studies and to encourage the scientific development of young investigators. Research within Joslin involves many biologic disciplines including molecular biology, protein biochemistry, studies of cultured cells and cell free systems, molecular and population genetics, genomics, analysis of mechanisms of autoimmunity, physiologic and pathophysiologic studies in man and animal models, and the study of new therapies in patients. Some of important historical discoveries and improvements in diabetes care worldwide—recognition that tight blood glucose control can slow or prevent diabetes complications, creation of treatment protocols to enable women with diabetes to have healthy babies, the identification of markers for pre-diabetes, and pioneering laser surgery for diabetic eye disease—were developed at Joslin.

Joslin researchers have won top awards and recognition from the National Academy of Sciences, the Institute of Medicine, the American Diabetes Association (ADA) and the Juvenile Diabetes Research Foundation (JDRF), among many others. The number of papers Joslin researchers present each year at the annual ADA Scientific Sessions surpasses any other organization. Joslin also offers one of the largest research training programs in the world, with more than 120 M.D. and Ph.D. fellows training at the center annually. The DERC consists of three clusters of activity which support 10 separate cores, a Computer Resource, and an Enrichment Program. The Core laboratories are the major components of the Joslin DERC and represent the most visible and important aspect of the DERC. They are used by every investigator at Joslin and are an integral part of Joslin research.

Cores

Advanced Microscopy : The Microscopy/Histology Core facilitates the ready availability of sophisticated morphological techniques by providing electron microscopic services, a confocal microscope facility, along with resource for protocols, analysis and interpretation...

Administration : The Administrative Core of the Joslin DERC serves several functions: (1) It provides for the overall direction, planning, and internal review of the grant supported activities; (2) coordinates the Pilot and Feasibility seed grant program; (3)..

Flow Cytometry : The Flow Cytometry Core Facility provides high speed cell sorting, multi-color fluorescence cell analysis and data interpretation to Joslin Investigators. The aim of this core facility is to provide a comprehensive service with high quality for..

Genomics : The Joslin Genomics Core is a core facility for the NIH-sponsored Diabetes Genome Anatomy Project (DGAP) and the Joslin Diabetes Center DERC PCR Core.The Diabetes Genome Anatomy Project (DGAP) represents a unique, multidimensional..

Protein, Proteomics & Mass Spec : Room 4505, MezzanineJoslin Diabetes CenterSenior Research Assistant: Jane ChenCore Director: Edward Feener

Media Core : To provide culture media and buffers for the investigators who are part of the DERC

Molecular Biology, Genomics & Genetics : The Genetics Core establishes, maintains, and distributes panels of DNA samples to be used by other investigators. It also..

Mouse Phenotyping Physiology & Metabolism : Rodent Models:1. Energy Homeostasis: Feeding behavior, body composition, oxygen consumption and activity monitoring.2. Vascular Studies: Blood pressure..

Assay & Analytical : Specialized assay services are performed for the bulk of the animal and human studies at the Joslin Diabetes Center. Please note that prices have changed for assay core tests as of June 1 2008.

Clinical Investigation & Informatics : The core will support computational data analysis at the Joslin. We will provide tools and coordinate access to software and software licenses for bioinformatics tools. The core supports all users, from novices to code writing experts...

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