$node = stdClass Object (
[nid] => [23099]
[vid] => [23238]
[type] => [biblio]
[status] => [1]
[created] => [1258739252]
[changed] => [1264712466]
[comment] => [2]
[promote] => [1]
[sticky] => [0]
[revision_timestamp] => [1264712466]
[title] => [Variants in MTNR1B influence fasting glucose levels.]
[body] => [<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info%3Asid%2Fwww.diabetescenters.org&rft.genre=article&rft.atitle=Variants+in+MTNR1B+influence+fasting+glucose+levels.&rft.title=Nature+genetics&rft.date=2009&rft.volume=41&rft.spage=77&rft.epage=81&rft.aulast=Prokopenko+I+++Ber&rft.aufirst=Langenberg+Florez+JC+Saxena+Soranzo+Thorleifsson+Loos+RJ+Manning+AK+Jackson+AU+Aulchenko+Potter+SC+Erdos+MR+Sanna+Hottenga+JJ+Wheeler+Kaakinen+Lyssenko+Chen+WM+Ahmadi+Beckmann+JS&rft_id=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fng.290"></span><div class="biblio_type"><h3>Publication Type:</h3> Journal Article</div>
<div class="biblio_authors"><h3>Authors:</h3> <a href="/biblio/author/Prokopenko+I">Prokopenko I , Langenberg C , Florez JC , Saxena R , Soranzo N , Thorleifsson G , Loos RJ , Manning AK , Jackson AU , Aulchenko Y , Potter SC , Erdos MR , Sanna S , Hottenga JJ , Wheeler E , Kaakinen M , Lyssenko V , Chen WM , Ahmadi K , Beckmann JS , Ber</a></div>
<div class="biblio_source"><h3>Source: </h3> Nature genetics, Volume 41, p.77-81 (2009)</div>
<h3>URL:</h3><a href="http://dx.doi.org/10.1038/ng.290">http://dx.doi.org/10.1038/ng.290</a>
<h3>Abstract:</h3> <p>{To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B</p>
]
[log] => []
[format] => [1]
[uid] => [1]
[name] => [admin]
[picture] => []
[data] => [a:0:{}]
[biblio_type] => [102]
[biblio_number] => []
[biblio_section] => []
[biblio_other_number] => []
[biblio_secondary_title] => [Nature genetics]
[biblio_tertiary_title] => []
[biblio_short_title] => []
[biblio_alternate_title] => []
[biblio_translated_title] => []
[biblio_authors] => [Prokopenko I , Langenberg C , Florez JC , Saxena R , Soranzo N , Thorleifsson G , Loos RJ , Manning AK , Jackson AU , Aulchenko Y , Potter SC , Erdos MR , Sanna S , Hottenga JJ , Wheeler E , Kaakinen M , Lyssenko V , Chen WM , Ahmadi K , Beckmann JS , Ber]
[biblio_secondary_authors] => []
[biblio_tertiary_authors] => []
[biblio_corp_author] => []
[biblio_other_author_affiliations] => []
[biblio_edition] => []
[biblio_publisher] => []
[biblio_original_publication] => []
[biblio_reprint_edition] => []
[biblio_place_published] => []
[biblio_year] => [2009]
[biblio_volume] => [41]
[biblio_number_of_volumes] => []
[biblio_pages] => [77-81]
[biblio_date] => []
[biblio_isbn] => []
[biblio_issn] => []
[biblio_lang] => [eng]
[biblio_abst_e] => [<p>{To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B</p>]
[biblio_abst_f] => []
[biblio_full_text] => [0]
[biblio_keywords] => []
[biblio_url] => [http://dx.doi.org/10.1038/ng.290]
[biblio_doi] => []
[biblio_issue] => []
[biblio_type_of_work] => []
[biblio_accession_number] => []
[biblio_call_number] => []
[biblio_notes] => []
[biblio_coins] => [<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info%3Asid%2Fwww.diabetescenters.org&rft.genre=article&rft.atitle=Variants+in+MTNR1B+influence+fasting+glucose+levels.&rft.title=Nature+genetics&rft.date=2009&rft.volume=41&rft.spage=77&rft.epage=81&rft.aulast=Prokopenko+I+++Ber&rft.aufirst=Langenberg+Florez+JC+Saxena+Soranzo+Thorleifsson+Loos+RJ+Manning+AK+Jackson+AU+Aulchenko+Potter+SC+Erdos+MR+Sanna+Hottenga+JJ+Wheeler+Kaakinen+Lyssenko+Chen+WM+Ahmadi+Beckmann+JS&rft_id=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fng.290"></span>]
[biblio_research_notes] => []
[biblio_custom1] => [http://www.ncbi.nlm.nih.gov/pubmed/19060907?dopt=Abstract]
[biblio_custom2] => [DK057521]
[biblio_custom3] => [19060907]
[biblio_custom4] => []
[biblio_custom5] => []
[biblio_custom6] => []
[biblio_custom7] => []
[biblio_auth_address] => []
[biblio_remote_db_name] => []
[biblio_remote_db_provider] => []
[biblio_citekey] => [19060907]
[biblio_label] => []
[biblio_access_date] => []
[biblio_type_name] => [Journal Article]
[path] => [biblio/variants-mtnr1b-influence-fasting-glucose-levels]
[nodewords] => []
[last_comment_timestamp] => [1258739255]
[last_comment_name] => []
[comment_count] => [0]
[taxonomy] => array (
[89] => stdClass (
[0] => [**Recursion Detected**]
)
)
[files] => []
[page_title] => []
[content] => array (
[body] => array (
[#value] => [<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info%3Asid%2Fwww.diabetescenters.org&rft.genre=article&rft.atitle=Variants+in+MTNR1B+influence+fasting+glucose+levels.&rft.title=Nature+genetics&rft.date=2009&rft.volume=41&rft.spage=77&rft.epage=81&rft.aulast=Prokopenko+I+++Ber&rft.aufirst=Langenberg+Florez+JC+Saxena+Soranzo+Thorleifsson+Loos+RJ+Manning+AK+Jackson+AU+Aulchenko+Potter+SC+Erdos+MR+Sanna+Hottenga+JJ+Wheeler+Kaakinen+Lyssenko+Chen+WM+Ahmadi+Beckmann+JS&rft_id=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fng.290"></span><div class="biblio_type"><h3>Publication Type:</h3> Journal Article</div>
<div class="biblio_authors"><h3>Authors:</h3> <a href="/biblio/author/Prokopenko+I">Prokopenko I , Langenberg C , Florez JC , Saxena R , Soranzo N , Thorleifsson G , Loos RJ , Manning AK , Jackson AU , Aulchenko Y , Potter SC , Erdos MR , Sanna S , Hottenga JJ , Wheeler E , Kaakinen M , Lyssenko V , Chen WM , Ahmadi K , Beckmann JS , Ber</a></div>
<div class="biblio_source"><h3>Source: </h3> Nature genetics, Volume 41, p.77-81 (2009)</div>
<h3>URL:</h3><a href="http://dx.doi.org/10.1038/ng.290">http://dx.doi.org/10.1038/ng.290</a>
<h3>Abstract:</h3> <p>{To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B</p>
]
[#printed] => [1]
)
[#children] => [<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info%3Asid%2Fwww.diabetescenters.org&rft.genre=article&rft.atitle=Variants+in+MTNR1B+influence+fasting+glucose+levels.&rft.title=Nature+genetics&rft.date=2009&rft.volume=41&rft.spage=77&rft.epage=81&rft.aulast=Prokopenko+I+++Ber&rft.aufirst=Langenberg+Florez+JC+Saxena+Soranzo+Thorleifsson+Loos+RJ+Manning+AK+Jackson+AU+Aulchenko+Potter+SC+Erdos+MR+Sanna+Hottenga+JJ+Wheeler+Kaakinen+Lyssenko+Chen+WM+Ahmadi+Beckmann+JS&rft_id=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fng.290"></span><div class="biblio_type"><h3>Publication Type:</h3> Journal Article</div>
<div class="biblio_authors"><h3>Authors:</h3> <a href="/biblio/author/Prokopenko+I">Prokopenko I , Langenberg C , Florez JC , Saxena R , Soranzo N , Thorleifsson G , Loos RJ , Manning AK , Jackson AU , Aulchenko Y , Potter SC , Erdos MR , Sanna S , Hottenga JJ , Wheeler E , Kaakinen M , Lyssenko V , Chen WM , Ahmadi K , Beckmann JS , Ber</a></div>
<div class="biblio_source"><h3>Source: </h3> Nature genetics, Volume 41, p.77-81 (2009)</div>
<h3>URL:</h3><a href="http://dx.doi.org/10.1038/ng.290">http://dx.doi.org/10.1038/ng.290</a>
<h3>Abstract:</h3> <p>{To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B</p>
]
[#printed] => [1]
)
[links] => array (
[comment_forbidden] => array (
[title] => [<a href="/user/login?destination=comment/reply/23099%2523comment-form">Login</a> to post comments]
[html] => [1]
)
)
);
